“Apple pectin for the reduction of niacin-induced flushing”Īuthors: P.M. It isn't harmful, but it can scare you if you don't know it's coming. The flush happens when the niacin causes the small blood vessels in your skin to dilate so more blood can rush through. “It is likely the apple pectin prolonged the absorption time of beyond the standard 8–12 hours, thereby resulting in a reduction of flushing symptoms,” they added. A niacin flush is a common side effect of taking large doses of niacin (vitamin B3) supplements. Results showed that both pectin and aspirin significantly lowered the duration of flushing, as well as other flushing parameters, compared with placebo.Ĭommenting on the potential mechanism, the researchers note that the pectin may be affecting niacin absorption by slowing gastrointestinal transit time, with other studies reporting that pectin can increase the time that it takes for food to pass through the stomach and intestine. Participants were randomly assigned to one of four groups to receive either apple pectin, apple pectin plus aspirin, aspirin only, or placebo, followed by a single high-dose of extended-release niacin (1,000 milligrams, ‘Niaspan’, Abbot Laboratories).įunding for this study was provided by Abbott Labs. This 'good' cholesterol helps remove low-density. Niacin has long been used to lower triglycerides and to increase high-density lipoprotein (HDL) cholesterol. One hundred niacin-naïve subjects were recruited to participate in their study. Niacin is an important B vitamin that may raise levels of high-density lipoproteins (HDL), the 'good' cholesterol, and lower triglycerides. “Because pectin is a common product considered to be extremely safe and possesses no dose limitations according to the Food and Agriculture Organization/World Health Organization, having patients consume dietary pectin (eg, apple), use a quality pectin supplement immediately before the administration of niacin, or encapsulating niacin with pectin, may limit niacin-induced flushing.” Writing in the Journal of Clinical Lipidology, the Kansas-based scientists state: “Although larger studies are needed to further support our pilot findings, there are potential applications from our study for clinical practice. New data from Patrick Moriarty, MD, and his co-workers indicated that taking a dose of apple pectin prior to a high dose of niacin can prevent flushing to the same extent as an aspirin. Higher doses, which are effective for reducing blood lipid levels, may cause flushing in the face and upper extremities.Īs an alternative, nicotinamide does not cause flushing, but this also does not have the same cholesterol reduction activity. In order to avoid the flushing linked with niacin, the tolerable upper limit is set at 35 milligrams per day, according to the Office of Dietary Supplements (ODS). The gut-brain axis: Psychobiotic opportunity in 25 countries.Uncovering white spaces – Probiotics for a smooth menopause transition.Uncovering White Spaces – Probiotics for Pets. POSTbiotics – New Tools in Microbiome Modulation.After the pandemic: Business lessons and insights from 25 probiotic supplement e-markets.
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